A new study finds that splicing disruption is a frequent consequence of mutations generated by CRISPR/Cas9 gene-editing technology, and alleles designed to be null can express aberrant proteins. This new information allows enhanced quality control procedures to select the best mutant alleles generated by CRISPR/Cas9.
CITATION STYLE
Sharpe, J. J., & Cooper, T. A. (2017). Unexpected consequences: Exon skipping caused by CRISPR-generated mutations. Genome Biology, 18(1). https://doi.org/10.1186/s13059-017-1240-0
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