Cytokines which promote emigration of leukocytes from the vascular lumen into the injured brain tissue are produced at the site of incipient cerebral infarction. The blood-borne invaders then accelerate the decomposition of brain cells by their toxic by-products, phagocytic action, and by the immune reaction. Recently accumulated data in our laboratories and other research facilities show that depleting the amount of circulating leukocytes or administering anti-inflammatory chemicals such as cytokine blocking agents, anti-adhesion molecule antibodies, and immunosuppressants effectively minimize the size of ischemia induced cerebral infarction. Based on the fact that leukocyte invasion of the affected brain tissue occurs 6 to 24 hours after onset of ischemia, administration of an anti-inflammatory therapy may widen the therapeutic window against stroke.
CITATION STYLE
Kogure, K., Yamasaki, Y., Matsuo, Y., Kato, H., & Onodera, H. (1996). Inflammation of the Brain after Ischemia. Acta Neurochirurgica, Supplement, 1996(66), 40–43. https://doi.org/10.1007/978-3-7091-9465-2_7
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