Evolution of Bone Disease Over Io years in 135 Patients with Terminal Renal Failure

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Abstract

An objective radiographic study of erosions, fractures, and periarticular and vascular calcification was made in a series of 135 patients over 10 years of maintenance haemodialysis therapy. The four lesions progressed at different rates, consistent with variation in the response of tissues to a changing biochemical milieu and deficiency in vitamin D metabolites. The half time for development of individual radiographic signs was 3.4 years for vascular calcification, 9 years for fractures, 16 years for periarticular calcification, and 22.9 years for erosions. Calcification of the dorsalis pedis artery seen as a developing ring or tube was an early and valuable sign of disturbed calcium metabolism. In these patients renal osteodystrophy is a chronic condition with a prolonged time course. © 1973, British Medical Journal Publishing Group. All rights reserved.

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Tatler, G. L. V., Baillod, R. A., Varghese, Z., Young, W. B., Wills, M. R., Moorhead, J. F., & Farrow, S. (1973). Evolution of Bone Disease Over Io years in 135 Patients with Terminal Renal Failure. British Medical Journal, 4(5888), 315–319. https://doi.org/10.1136/bmj.4.5888.315

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