We have previously shown high rates of co-infection with Respiratory Syncytial Virus (RSV) and human Metapneumovirus (hMPV) in infants with severe bronchiolitis at our institution in 2000-2002, and that co-infection was associated with increased disease severity. In this study, we have attempted to identify differences in intubated infants with severe RSV infection with and without hMPV co-infection. Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV- infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable. © 2007 Wiley-Liss, Inc.
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McNamara, P. S., Flanagan, B. F., Smyth, R. L., & Hart, C. A. (2007). Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis. Pediatric Pulmonology, 42(8), 740–743. https://doi.org/10.1002/ppul.20649