New mechanisms of glucocorticoid-induced insulin resistance: Make no bones about it

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Abstract

Glucocorticoids are a powerful tool used to treat a range of human illnesses, including autoimmune diseases and cancer, and to prevent rejection following organ transplantation. While lifesaving for many, they come with a steep price, often leading to obesity, insulin resistance, diabetes, and osteoporosis. In this issue of the JCI, Brennan-Speranza and colleagues provide evidence that the osteoblast-derived peptide osteocalcin is one of the drivers of the metabolic derangements associated with glucocorticoid therapy. This novel mechanism could open up new avenues for the treatment of these disorders.

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APA

Ferris, H. A., & Kahn, C. R. (2012, November 1). New mechanisms of glucocorticoid-induced insulin resistance: Make no bones about it. Journal of Clinical Investigation. https://doi.org/10.1172/JCI66180

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