Airway-stabilizing effect of long-acting β2-agonists as add-on therapy to inhaled corticosteroids

N/ACitations
Citations of this article
19Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: The protection afforded by long-acting β2-agonists against bronchoconstrictor stimuli can be regarded as a surrogate for their stabilizing effects on airway smooth muscle. Aim: To determine the magnitude of residual bronchoprotection after chronic dosing with long-acting β2-agonists. Design: Retrospective meta-analysis Methods: Medline, BIDS and Cochrane Library databases were searched from 1990. A meta-analysis was then performed of 13 eligible randomized placebo-controlled trials (596 patients) in which second-line treatment with a long-acting β2-agonist (salmeterol or formoterol) was used for 1 week or more. The residual protection against bronchoconstrictor stimuli as doubling dose/dilution shift was the main outcome measure. Results: Data were assessed according to Quorum criteria. Combining the results of the meta-analysis, the overall estimated protection amounted to a 0.79 (95%CI 0.63-0.96) doubling dose/dilution shift from placebo. Subgroup analysis showed greater protection at peak vs. trough, but no difference between formoterol vs. salmeterol, or between direct vs. indirect challenge. There was no evidence of significant heterogeneity across all the studies, or within any of the subgroups. Discussion: When used as second-line treatment, the overall additive protective effect of long-acting β2-agonists amounts to a 0.8 doubling dose/dilution shift. This stabilizing effect on airway smooth muscle may explain their beneficial effects on exacerbations.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Currie, G. P., Jackson, C. M., Ogston, S. A., & Lipworth, B. J. (2003). Airway-stabilizing effect of long-acting β2-agonists as add-on therapy to inhaled corticosteroids. QJM: An International Journal of Medicine, 96(6), 435–440. https://doi.org/10.1093/qjmed/hcg071

Readers over time

‘11‘13‘14‘15‘16‘17‘18‘19‘21‘22‘24‘2502468

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 9

50%

Researcher 5

28%

Professor / Associate Prof. 3

17%

Lecturer / Post doc 1

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 12

75%

Nursing and Health Professions 2

13%

Pharmacology, Toxicology and Pharmaceut... 1

6%

Agricultural and Biological Sciences 1

6%

Save time finding and organizing research with Mendeley

Sign up for free
0