Chemical constituents of Dendrobium venustum and their antimalarial and anti-herpetic properties

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Abstract

A MeOH extract from the whole plant Dendrobium venustum exhibited significant antimalarial and anti-herpetic activities. Bioassay-guided isolation of the plant extract resulted in the isolation of seven known phenolic compounds. Densiflorol B (3) and phoyunnanin E (6) showed the strongest antimalarial activity and a high selectivity index, whereas gigantol (2), batatasin III (5) and phoyunnanin C (7) exhibited moderate activity. Compounds 2 and 5 also showed weak activity against the Herpes simplex virus. This study is the first report on the chemical and biological activities of D. venustum.

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Sukphan, P., Sritularak, B., Mekboonsonglarp, W., Lipipun, V., & Likhitwitayawuid, K. (2014). Chemical constituents of Dendrobium venustum and their antimalarial and anti-herpetic properties. Natural Product Communications, 9(6), 825–827. https://doi.org/10.1177/1934578x1400900625

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