Transcranial random noise stimulation of visual cortex: Stochastic resonance enhances central mechanisms of perception

Abstract

Random noise enhances the detectability of weak signals in nonlinear systems, a phenomenon known as stochastic resonance (SR). Though counterintuitive at first, SR has been demonstrated in a variety of naturally occurring processes, including human perception, where it has been shown that adding noise directly to weak visual, tactile, or auditory stimuli enhances detection performance. These results indicate that random noise can push subthreshold receptor potentials across the transfer threshold, causing action potentials in an otherwise silent afference. Despite the wealth of evidence demonstrating SR for noise added to a stimulus, relatively few studies have explored whether or not noise added directly to cortical networks enhances sensory detection. Here we administered transcranial random noise stimulation (tRNS; 100–640 Hz zero-mean Gaussian white noise) to the occipital region of human participants. For increasing tRNS intensities (ranging from 0 to 1.5 mA), the detection accuracy of a visual stimuli changed according to an inverted-Ushaped function, typical of the SR phenomenon. When the optimal level of noise was added to visual cortex, detection performance improved significantly relative to a zero noise condition (9.7 ± 4.6%) and to a similar extent as optimal noise added to the visual stimuli (11.2 ± 4.7%). Our results demonstrate that adding noise to cortical networks can improve human behavior and that tRNS is an appropriate tool to exploit this mechanism.