Abstract
Gallium nitrate, administered intravenously to patients with advanced cancer, produced renal functional abnormalities consistently at a dose of 750 mg/m2. The toxicity at that dose could be modified by fluid loading and osmotic diuresis. Pharmacokinetic studies revealed a biphasic half‐life, (T 1/2α = 87 minutes and T 1/2β = 24.5 hours). Osmotic diuresis reduced the urinary concentration of gallium but did not affect serum levels or clearance. Copyright © 1979 American Cancer Society
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CITATION STYLE
Krakoff, I. H., Newman, R. A., & Goldberg, R. S. (1979). Clinical toxicologic and pharmacologic studies of gallium nitrate. Cancer, 44(5), 1722–1727. https://doi.org/10.1002/1097-0142(197911)44:5<1722::AID-CNCR2820440528>3.0.CO;2-C
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