Discuss the epithelial to mesenchymal transition by the view of mechanics

Abstract

The epithelial to mesenchymal transition (EMT) involves several physiological and pathological phenomena and endows cells with invasive and migratory properties. We use the microplate measurement system (MMS) to measure cells stiffness. The EMT cells will have higher stiffness. However, treating inhibitor Cyto-D and ML-7 will lower cells’ stiffness. Based on this, we can use mechanical properties, to be a principle of the EMT process.