Drug Repositioning by Mining Adverse Event Data in ClinicalTrials.gov

Abstract

The protocol below describes an in silico method for drug repositioning (drug repurposing). The data source is ClinicalTrials.gov, which contains about a quarter of a million clinical studies. Mining such rich and clean clinical summary data could be helpful to many health-related researches. Described here is a method that utilizes serious adverse event data to identify potential new uses of drugs and dietary supplements (repositioning).