Metallothionein has been postulated to function in essential metal homeostasis. In this study, we demonstrate a 1.7-fold increase in purified bovine liver delta-aminolevulinic acid dehydratase (ALAD) activity following incubation with purified kidney Zn-thionein isolated from Zn-treated rats. The mechanism of enzyme activation, as demonstrated using 65Zn-labeled thionein, involves direct transfer of Zn from Zn-thionein to ALAD. These data support the hypothesis that metallothionein serves to regulate the intracellular bioavailability of essential cations, functioning as a reservoir or conduit through which metals are donated to enzymes which require them as cofactors.
CITATION STYLE
Goering, P. L., & Fowler, B. A. (1987). Activation of delta-aminolevulinic acid dehydratase following donation of zinc from kidney metallothionein. Experientia. Supplementum, 52, 613–616. https://doi.org/10.1007/978-3-0348-6784-9_64
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