The total synthesis of (±)-nicolaioidesin B, a natural product that shows preferential cytotoxicity against pancreatic cancer cells under nutrient starvation conditions, is achieved. The key step is a thermally-induced, highly regio- and diastereoselective Diels-Alder reaction between (E)-N-methoxy-N-methylcinnamide and ocimene under solvent-free conditions.
CITATION STYLE
Pigott, A. J., Lepage, R. J., White, J. M., & Coster, M. J. (2014). Total synthesis of (±)-nicolaioidesin B via a highly regio- and diastereoselective Diels-Alder reaction. Tetrahedron Letters, 55(50), 6864–6867. https://doi.org/10.1016/j.tetlet.2014.10.097
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