The intent of this chapter is to highlight the contributions of large animal models including pigs, sheep, goats, dogs, and nonhuman primates. These species are crucial for clinical translation of new cell and tissue engineering approaches for the treatment of human diseases. Choice of species, age, and model validation are necessary to ensure outcomes are predictive, and recapitulate human development, anatomy, physiology, and disease. The overriding objective is to select a model that can reliably assess the safety and efficacy of new therapies beyond the discovery phase and to obtain results that can be translated to clinical trials in children and adults.
CITATION STYLE
Daly, K. A., Brown, B. N., & Badylak, S. F. (2011). Regenerative Medicine and the Foreign Body Response. In Tissue Engineering in Regenerative Medicine (pp. 353–375). Humana Press. https://doi.org/10.1007/978-1-61779-322-6_19
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