The acute effect of the antioxidant drug "U-74389G" on platelet-crit levels during hypoxia reoxygenation injury in rats

Abstract

Aim: The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in an hypoxia-reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule were studied hematologically using blood mean platelet-crit (pct) levels. Methods: Forty rats of mean weight 231.875 g were used in the study. Pct levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D), A and B without but C and D with U-74389G administration. Results: U-74389G administration non-signiflcantly increased the pct levels by 9.23±6.29% (P=0.1064). Reoxygenation time non-signiflcantly increased the pct levels by 3.76±6.44% (P=0.4803). However, U-74389G administration and reoxygenation time together non-signiflcantly increased the pct levels by 6.72±3.73% (P=0.0712). Conclusion: U-74389G administration wheter it interacted or not with reperfusion time, did not increase pct levels significantly in the short-term. Perhaps, a longer study time may result in significant alterations.