Germline variation in colorectal risk loci does not influence treatment effect or survival in metastatic colorectal cancer

Abstract

Background: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. Methods: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a phase III clinical trial of first-line chemotherapy for metastatic CRC. Results: rs10795668 was weakly associated with TTP (p = 0.02), but not RR or OS. No other SNPs carried statistically significant HRs for any of the primary outcomes (RR, TTP or OS). Conclusion: Common low-penetrance CRC risk SNPs were not associated with outcomes among patients with metastatic CRC. © 2014 Sanoff et al.