Alternative and complementary approaches for the treatment of inflammatory bowel disease: Evidence from cochrane reviews

Abstract

Fecal microbial transplantation increased the proportion of patients achieving clinical remission and endoscopic remission in mild to moderate UC. However, the number of included studies was small, and the quality of evidence was low. No studies assessed FMT for maintenance of remission in UC. There was uncertainty about the effect of FMT on serious adverse events due to the low number of events and short duration of follow-up. As a result, no solid conclusions can be drawn at this time. Additional high-quality RCTs are required to determine the optimal fecal composition and processing methods, route of administration, and frequency and volume of treatment. No studies assessed the efficacy of FMT for induction or maintenance of remission in CD or in pediatric participants.