Introduction: We aimed to estimate the prevalence and transmission of drug-resistant tuberculosis in a high-burden Brazilian setting under directly observed therapy short-course strategy. Methods: Isolates of culture-confirmed pulmonary tuberculosis patients from Guarulhos, Brazil, diagnosed in October 2007–2011 were subjected to drug susceptibility and IS6110–restriction fragment length polymorphism testing. Results: The overall resistance prevalence was 11.5% and the multi-drug resistance rate was 4.2%. Twenty-six (43.3%) of 60 drug-resistant isolates were clustered. Epidemiological relationships were identified in 11 (42.3%) patients; 30.8% of the cases were transmitted in households. Conclusions: Drug-resistant tuberculosis was relatively low and transmitted in households and the community.
Latrilha, F. O., Simonsen, V., Pinhata, J. M. W., Brandão, A. P., Galesi, V. M. N., Waldman, E. A., & Ferrazoli, L. (2020). Transmission and prevalence of drug-resistant tuberculosis in a brazilian setting under a directly observed therapy short-course strategy. Revista Da Sociedade Brasileira de Medicina Tropical, 53, 1–7. https://doi.org/10.1590/0037-8682-0404-2019