Bioreactors can offer an advanced platform to provide conditions that mimic the native microenvironment, which can also provide stretching environment for mechanobiology research. Tendon-derived stem cells (TDSCs) are a type of mechanosensitive and multipotent cells, which behave differently in diverse mechanical stretching environments. We have proved the in vitro three-dimensional (3D) mechanical stimulation could closely mimic the stretching environment in vivo. Thus, here we describe applying a customized bioreactor to provide 3D force for mechanical stimulation on TDSC in vitro.
CITATION STYLE
Chen, Z., Chen, P., Ruan, R., & Zheng, M. (2022). In Vitro 3D Mechanical Stimulation to Tendon-Derived Stem Cells by Bioreactor. In Methods in Molecular Biology (Vol. 2436, pp. 135–144). Humana Press Inc. https://doi.org/10.1007/7651_2021_432
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