Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder

18Citations
Citations of this article
53Readers
Mendeley users who have this article in their library.

Abstract

Background We previously reported that patients with early-stage bipolar disorder, but not healthy comparison controls, had body mass index (BMI)-related volume reductions in limbic brain areas, suggesting that the structural brain changes characteristic of bipolar disorder were more pronounced with increased weight. Aims To determine whether the most consistently reported neurochemical abnormality in bipolar disorder, increased glutamate/glutamine (Glx), was also more prominent with higher BMI. Method We used single-voxel proton magnetic resonance spectroscopy to measure hippocampal Glx in 51 patients with first-episode mania (mean BMI = 24.1) and 28 healthy controls (mean BMI = 23.3). Results In patients, but not healthy controls, linear regression demonstrated that higher BMI predicted greater Glx. Factorial ANCOVA showed a significant BMI6diagnosis interaction, confirming a distinct effect of weight on Glx in patients. Conclusions Together with our volumetric studies, these results suggest that higher BMI is associated with more pronounced structural and neurochemical limbic brain changes in bipolar disorder, even in early-stage patients with low obesity rates.

References Powered by Scopus

A new depression scale designed to be sensitive to change

11888Citations
N/AReaders
Get full text

Advances in functional and structural MR image analysis and implementation as FSL

10756Citations
N/AReaders
Get full text

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: A systematic analysis for the Global Burden of Disease Study 2013

9325Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: A systematic review

113Citations
N/AReaders
Get full text

Call to action regarding the vascular-bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders

78Citations
N/AReaders
Get full text

Neurococognitive and neuroimaging correlates of obesity and components of metabolic syndrome in bipolar disorder: A systematic review

54Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Bond, D. J., Da Silveira, L. E., MacMillan, E. L., Torres, I. J., Lang, D. J., Su, W., … Yatham, L. N. (2016). Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder. In British Journal of Psychiatry (Vol. 208, pp. 146–152). Royal College of Psychiatrists. https://doi.org/10.1192/bjp.bp.115.163360

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 24

80%

Researcher 6

20%

Readers' Discipline

Tooltip

Medicine and Dentistry 16

52%

Psychology 8

26%

Neuroscience 4

13%

Biochemistry, Genetics and Molecular Bi... 3

10%

Save time finding and organizing research with Mendeley

Sign up for free