Drug dosing in patients with chronic kidney disease and dermatological diseases

Abstract

Dermatological disorders are common among CKD population and dosage adjustment for systemically administered medications is a challenge in this population. Directly or indirectly, the kidney plays a vital role in drug elimination. Chronic kidney disease may alter the pharmacokinetic properties of most drugs including drug absorption, distribution, metabolism, and excretion processes. In addition, most patients with chronic kidney disease (CKD) are elderly with multiple comorbidities such as dermatological disorders requiring systemic therapy which place them at high risk for drug-related problems. There are few absolute contraindications for use of drugs in CKD; however, for most drugs, dosage adjustment is required to avoid toxic accumulation of drug or metabolites.