Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis

23Citations
Citations of this article
31Readers
Mendeley users who have this article in their library.

Abstract

In monocentric organisms with asymmetric meiosis, the kinetochore proteins, such as CENH3 and CENP-C, evolve adaptively to counterbalance the deleterious effects of centromere drive, which is caused by the expansion of centromeric satellite repeats. The selection regimes that act on CENH3 and CENP-C genes have not been analyzed in organisms with holocentric chromosomes, although holocentrism is speculated to have evolved to suppress centromere drive. We tested both CENH3 and CENP-C for positive selection in several species of the holocentric genus Caenorhabditis using the maximum likelihood approach and sliding-window analysis. Although CENP-C did not show any signs of positive selection, positive selection has been detected in the case of CENH3. These results support the hypothesis that centromere drive occurs in Nematoda, at least in the telokinetic meiosis of Caenorhabditis. © 2012 Zedek, Bureš.

Cite

CITATION STYLE

APA

Zedek, F., & Bureš, P. (2012). Evidence for centromere drive in the holocentric chromosomes of Caenorhabditis. PLoS ONE, 7(1). https://doi.org/10.1371/journal.pone.0030496

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free