Various novelty-based assays used to quantify zebrafish (Danio rerio) behavior show a striking similarity to behavioral responses in rodents. Exposed to the open field test, zebrafish establish overt homebases demonstrating clear preference for a particular area of the tank. This behavior aims to establish a "safe zone" that zebrafish can familiarize themselves with and feel secure in, and is similar to homebase behaviors of various laboratory rodent species. Here we outline a simple protocol for homebase phenotyping in zebrafish. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Stewart, A., Cachat, J. M., Wong, K., Wu, N., Grossman, L., Suciu, C., … Kalueff, A. V. (2011). Phenotyping of zebrafish homebase behaviors in novelty-based tests. Neuromethods, 51, 143–155. https://doi.org/10.1007/978-1-60761-953-6_12
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