Assessment of cellular and humoral immunity of myasthenics

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Abstract

A close association of autoimmune diseases or autoimmune phenomena in myasthenia gravis is well known. A comprehensive immunological study of 22 patients with myasthenia gravis showed that changes in the immune system mainly involve the thymusderived lymphocytes (T cells). Anti-thymus antibody was present in 90% of the patients, and it paralleled the frequency of thymic abnormality in myasthenia gravis. It is postulated that in myasthenia gravis the altered T cell functions caused by anti-thymus antibody result in the formation of an array of autoantibodies including the factor which blocks the neuromuscular transmission.

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Huang, S. W., Rose, J. W., & Mayer, R. F. (1977). Assessment of cellular and humoral immunity of myasthenics. Journal of Neurology, Neurosurgery and Psychiatry, 40(11), 1053–1059. https://doi.org/10.1136/jnnp.40.11.1053

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