Background/aims: The frequency of Human Leucocyte Antigens/alleles associated with rapid progression from Human Immunodeficiency Virus infection to Acquired Immunodeficiency Syndrome was evaluated in Brazilian patients with Acquired Immunodeficiency Syndromewith and without Toxoplasmic Encephalitis. Methods: 114 patients with Acquired Immunodeficiency Syndrome (41 with Toxoplasmic Encephalitis, 43 with anti-Toxoplasma gondii antibodies, without Toxoplasmic Eencephali-tis, and 30 without anti-Toxoplasma gondii antibodies circulating and without Toxoplasmic Encephalitis) were studied. Results: Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome, particularly HLA-B35, -DR3, and -DR1 allele group, weresignificantly less represented in patients with Toxoplasmic Encephalitis and Acquired Immunodeficiency Syndrome. Conclusion: The presence of these Human Leucocyte Antigens/Alleles that predispose to Acquired Immunodeficiency Syndrome progression was associated with resistance to Tox-oplasmic Encephalitis among Human Immunodeficiency Virus-1 carriers.
CITATION STYLE
Rodrigues, M. de L., Deghaide, N. H., Figueiredo, J. F., de Menezes, M. B., Demarco, A. L., Donadi, E., & Fernandes, A. P. (2016). Toxoplasmic encephalitis: Role of Human Leucocyte Antigens/alleles associated with rapid progression to Acquired Immunodeficiency Syndrome. Brazilian Journal of Infectious Diseases, 20(2), 115–118. https://doi.org/10.1016/j.bjid.2015.10.010
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