The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving a fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.
CITATION STYLE
Godfrey, D. G., Stimson, W. H., Watson, J., Belch, J. F., & Sturrock, R. D. (1986). Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: A preliminary investigation. Annals of the Rheumatic Diseases, 45(12), 1019–1024. https://doi.org/10.1136/ard.45.12.1019
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