Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: A preliminary investigation

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Abstract

The effects of dietary fatty acid supplementation on various disease parameters in the spontaneously autoimmune MRL-mp-lpr/lpr mouse model of systemic lupus erythematosus before onset of disease were investigated. A fat deficient diet was supplemented with the following oils: olive oil, sunflower oil, evening primrose oil (EPO), fish oil, and a fish oil/EPO mixture. The mice receiving a diet enriched with EPO showed an increase in survival, as did those receiving a fish oil/EPO mixture. These results, taken together with those of the other parameters monitored, suggest that EPO may be of benefit in alleviating the murine form of the disease.

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Godfrey, D. G., Stimson, W. H., Watson, J., Belch, J. F., & Sturrock, R. D. (1986). Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: A preliminary investigation. Annals of the Rheumatic Diseases, 45(12), 1019–1024. https://doi.org/10.1136/ard.45.12.1019

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