Prospective observational study of surgery alone for locally advanced oral squamous cell carcinoma: a real-world study

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Abstract

Introduction: A prospective observational study was modified to assess the efficacy of surgery alone for the treatment of locally advanced oral squamous cell carcinoma. (LA-OSCC) Materials and methods: This prospective, single-institution, single-arm study involved 174 patients who underwent major surgery for LA-OSCC. Participating patients did not receive postoperative radiation. After initial curative treatment, patients were routinely monitored via clinical examination and imaging. The follow-up period was 3–70 months. Tumour recurrence and death were considered as the Clinical End Point in Research. Results: The 5-year overall survival (OS), disease-free survival (DFS), and locoregional control rates for 174 patients were 66.7% (95% confidence interval [CI], 59.8 to 73.6), 66.1% (95% CI, 59.2 to 73.0), and 82.4% (95% CI, 76.5 to 88.3), respectively. Conclusion: A study of patients with LA-OSCC treated with surgery alone may have the optimal therapeutic impact for LA-OSCC, as evidenced by solid data for our next RCT trial. This conclusion still needs to be validated in higher-level RCTs.

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Ren, Z. H., Liu, K., Chen, Y., Yang, Z. M., Wu, K., & Wu, H. J. (2024). Prospective observational study of surgery alone for locally advanced oral squamous cell carcinoma: a real-world study. BMC Oral Health, 24(1). https://doi.org/10.1186/s12903-024-03914-6

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