Synthesis of functionalized 4H-chromenes catalyzed by lipase immobilized on magnetic nanoparticles

Abstract

In the work, mucor miehei lipase (MML) was covalently immobilized on the 2,4,6-trichloro-1,3,5- triazine (TCT)-modified magnetite nanoparticles. Then, the immobilized MML was utilized in the synthesis of functionalized 4H-Chromenes via a multicomponent reaction firstly. Under the optimized reaction conditions, immobilized MML displayed high catalytic performance (Yield: 81–96%) and excellent reusability, indicating a high potential for practical operation.