Clostomicins, New Antibiotics Produced by Micromonospora Echinospora Subsp. Armeniaca Subsp. Nov. I. Production, Isolation, and Physico-Chemical and Biological Properties

Abstract

A soil isolate named as Micromonospora echinospora subsp. armeniaca subsp. nov. KMR-593 was found to produce at least five related antibiotics, clostomicins, active against Gram-positive bacteria including anaerobes. From the physico-chemical properties, one of these components was identified with lipiarmycin and others were found to be new antibiotics. Each component includes two chlorine atoms and the molecular weights of A and B2, C, and D are 1, 058, 1, 042 and 1, 056, respectively. The structural differences were characterized by NMR analyses. © 1986, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.