New spinosin derivatives from the seeds of Ziziphus mauritiana

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Abstract

Three new acylated flavonoid C-glycosides, 6‴-(-)-phaseoylspinosin (1), 6‴-(3″″,4″″,5″″-trimethoxyl)-(E)-cinnamoylspinosin (2), and 6‴-(4″″-O-β-D-gluco-pyranosyl)-benzoylspinosin (3), were isolated from the seeds of Ziziphus mauritiana (Rhamnaceae). A further 19 known compounds including eight spinosin analogues (4–11) were also isolated. Their structures were elucidated by means of spectroscopic analysis and chemical method. Among spinosin derivatives 1, 2, 4, 7, 8, and triterpenoid saponin 14, jujuboside A (14) displayed moderate acetylcholinesterase (AchE) inhibitory activity with an inhibition value of 46.2% at a concentration of 1 µM. [Figure not available: see fulltext.].

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Wang, B., Zhu, H. T., Wang, D., Yang, C. R., Xu, M., & Zhang, Y. J. (2013). New spinosin derivatives from the seeds of Ziziphus mauritiana. Natural Products and Bioprospecting, 3(3), 93–98. https://doi.org/10.1007/s13659-013-0028-5

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