Vitamin A rich diet diminishes early urothelial carcinogenesis by altering retinoic acid signaling

12Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Urinary bladder cancer is one of the leading malignancies worldwide, with the highest recurrence rates. A diet rich in vitamin A has proven to lower the risk of cancer, yet the molecular mechanisms underlying this effect are unknown. We found that vitamin A decreased urothelial atypia and apoptosis during early bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN). Vitamin A did not alter urothelial cell desquamation, differentiation, or proliferation rate. Genes like Wnt5a, involved in retinoic acid signaling, and transcription factors Pparg, Ppara, Rxra, and Hoxa5 were downregulated, while Sox9 and Stra6 were upregulated in early urothelial carcinogenesis. When a vitamin A rich diet was provided during BBN treatment, none of these genes was up-or downregulated; only Lrat and Neurod1 were upregulated. The lecithin retinol acyltransferase (LRAT) enzyme that produces all-trans retinyl esters was translocated from the cytoplasm to the nuclei in urothelial cells as a consequence of BBN treatment regardless of vitamin A rich diet. A vitamin A-rich diet altered retinoic acid signaling, decreased atypia and apoptosis of urothelial cells, and consequently diminished early urothelial carcinogenesis.

References Powered by Scopus

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

66844Citations
N/AReaders
Get full text

Cancer statistics, 2013

11918Citations
N/AReaders
Get full text

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

5710Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Vitamin A and retinoids in bladder cancer chemoprevention and treatment: A narrative review of current evidence, challenges and future prospects

23Citations
N/AReaders
Get full text

Study of the Anti-Inflammatory Mechanism of β-Carotene Based on Network Pharmacology

10Citations
N/AReaders
Get full text

Insights into vitamin A in bladder cancer, lack of attention to gut microbiota?

6Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zupančič, D., Korać-Prlić, J., Kreft, M. E., Franković, L., Vilović, K., Jeruc, J., … Terzić, J. (2020). Vitamin A rich diet diminishes early urothelial carcinogenesis by altering retinoic acid signaling. Cancers, 12(7), 1. https://doi.org/10.3390/cancers12071712

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

60%

Professor / Associate Prof. 1

20%

Researcher 1

20%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 3

50%

Agricultural and Biological Sciences 1

17%

Medicine and Dentistry 1

17%

Immunology and Microbiology 1

17%

Save time finding and organizing research with Mendeley

Sign up for free