Influence of oophorectomy on glycemia and lipidogram

Abstract

Purpose: To verify the influence of oophorectomy on lipidogram and glycemia. Methods: Fifty six female rats were divided into the following 7 groups (n = 8): group 1 – sham group, group 2 – oophorectomy 30 days, group 3 – oophorectomy 35 days, group 4 – oophorectomy 40 days, group 5 – oophorectomy 45 days, group 6 – oophorectomy 70 days, group 7 – oophorectomy 55 days. Animals were following by number of days according the group. Was evaluated the serum levels of glucose and lipid profile. Results: The oophorectomized rats presented higher glycemia. Groups 3, 4, 6 and 7 had a higher glycemia and LDL levels (except for group 6) and groups 6 and 7 had lowest levels of HDL. Group 7 had highest level of VLDL than oophorectomy groups. There was no difference in triglycerides levels. Conclusion: Oophorectomy was related to dyslipidemia and insulin resistance, mainly after 50th days.