Synthesis and Characterization of Chitosan Membrane as a Matrix in Drug Delivery of Curcumin

Abstract

This study aims to find out how to synthesize the chitosan membrane contained curcumin and its characteristics. The characterization of chitosan membrane was determined use FTIR for functional group analysis, XRD for crystallinity and SEM to show the surface of morphology and cross-section on the chitosan membrane. Curcumin encapsulated into the chitosan membrane was performed by using UV-Vis spectrophotometry at λ 426 nm. The results of this study indicate that the chitosan membrane synthesized was obtained homogeneous clear yellow membrane sheets. The characterization of FTIR instrument obtained that chitosan membrane have peaks at wavenumber of 3425.58 cm-1 that show OH groups and 1627.92 cm-1 which show the presence of amine groups. While XRD characterization show chitosan membrane was semi-crystalline which was shown by a high peak intensity with angles 2θ 4.1604 and 2θ 3.8711. According to the SEM photo shows a smooth and even surface morphology. The optimum time for encapsulation of curcumin into the chitosan membrane is 60 minutes with % EE of 14%.