Control of mitochondrial activity by miRNAs

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Abstract

Mitochondria supply energy for physiological function and they participate in the regulation of other cellular events including apoptosis, calcium homeostasis, and production of reactive oxygen species. Thus, mitochondria play a critical role in the cells. However, dysfunction of mitochondria is related to a variety of pathological processes and diseases. MicroRNAs (miRNAs) are a class of small noncoding RNAs about 22 nucleotides long, and they can bind to the 3′-untranslated region (3′-UTR) of mRNAs, thereby inhibiting mRNA translation or promoting mRNA degradation. We summarize the molecular regulation of mitochondrial metabolism, structure, and function by miRNAs. Modulation of miRNAs levels may provide a new therapeutic approach for the treatment of mitochondria-related diseases. © 2011 Wiley Periodicals, Inc.

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Li, P., Jiao, J., Gao, G., & Prabhakar, B. S. (2012). Control of mitochondrial activity by miRNAs. Journal of Cellular Biochemistry, 113(4), 1104–1110. https://doi.org/10.1002/jcb.24004

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