Antibacterial activity of zinc oxide nanoparticle (ZnONP) biosynthesis by lactobacillus plantarium aganist pathogenic bacteria

Abstract

The good capability of zinc-tolerant probiotic of Lactobacillus plantarum tolerating high concentrations of Zinc+2 and producing Zinc Oxide Nanoparticles high lights the unique characteristics of these bacteria as a natural microbial cell nano-factory for a more efficient and environmentally friendly process of biosynthesis of these nanoparticles. The morphology structure and stability of the synthesized ZnO nanoparticles were studied using structural and morphological Properties technology such as XRD and FE-SEM analysis it also used optical properties such as UV and FTIR spectrum. The results depicted that the synthesized nanoparticles were moderately stable, exagonal phase, roughly spherical with maximum particles in size range within7–19 nm in diameteralso this study include the antibacterial activity of the Zinc Oxide Nanoparticles on some pathogenic bacteria.It is clear in this the study that Zinc Oxide Nanoparticles has stronger inhibitory effect on pathogenic bacteria because The proposed two imaginable mechanisms for the antibacterial action of zinc oxide nanoparticles to bacteria are first, creation of augmented levels of ROS mostly hydroxyl radical and singlet oxygen which destruction the bacterial cell wall. Second nanoparticles deposition on bacterial surface or nanoparticles aggregation either in the periplasm region or in the cytoplasm initiating distraction of cellular function and membranes disorganization.