Cloning IL-1 and the Birth of a New Era in Cytokine Biology

Abstract

In December of 1984, the sequence of the cDNA encoding for the human precursor of IL-1 was reported in a seminal paper by Charles Dinarello’s group ([1][1]). This work is the subject of this month’s selected paper for Pillars of Immunology based on its significant impact on the field of cytokine