Efficacy of recombinant human soluble thrombomodulin in disseminated intravascular coagulation

Abstract

Soluble thrombomodulin is a promising therapeutic natural anticoagulant that is comparable with antithrombin, tissue factor pathway inhibitor and activated protein C. Recently, a recombinant human soluble thrombomodulin, composed of the active, extracellular domain of thrombomodulin, has become commercially available for patients with disseminated intravascular coagulation (DIC). However, its effect on adhesion molecule or plasminogen activator inhibitor 1 (PAI-1) in patients with DIC is not clear. To elucidate the possible effect of a soluble thrombomodulin on endothelial cell and neutrophil interaction in DIC, we investigated the efficacy of a recombinant human soluble thrombomodulin against not only soluble fibrin (SF) for the sensitive marker of DIC, but also soluble E-selectin (sES) and PAI-1 in patients with DIC.