Signaling for meiotic resumption in granulosa cells, cumulus cells, and oocyte

Abstract

Mammalian oocytes are arrested in prophase of meiosis I until a surge of luteinizing hormone from the pituitary signals them to resume meiosis and progress to metaphase II. Prophase arrest prior to the LH surge, and meiotic resumption following the LH surge, are regulated by an interplay between the oocyte and the surrounding follicle cells. This chapter reviews what is currently known about the maintenance of meiotic arrest and the mechanisms that bring about meiotic resumption in the rodent oocyte.