Serum phosphorus levels are associated with carotid intima-media thickness in asymptomatic postmenopausal women

Abstract

Objective: Serum phosphorous is a significant risk factor for increased carotid intima-media thickness. Increased thickness of the carotid intima is a known cause of cardiovascular disease. Coronary heart disease is a significant cause of mortality and morbidity in postmenopausal women. This study aimed to compare the relationship between serum phosphorous concentration and carotid intima-media thickness in healthy asymptomatic postmenopausal women. Methods: A retrospective review of the medical records from a health checkup center in Gangnam Severance hospital between March 2007 and September 2017 was conducted. We examined asymptomatic postmenopausal female patients with age range between 56 and 66 (N ¼ 361) who underwent measurement of carotid intima-media thickness by B-mode ultrasonography. The physiological variables analyzed included mean blood pressure, body mass index, renal function (serum creatinine and estimated glomerular filtration rate), cholesterol levels (total cholesterol, triglyceride, and high- and low-density lipoprotein), serum phosphorous, calcium, electrolytes, diabetic status, hypertension, and albumin. Results: Pearson correlation test showed that carotid intima-media thickness was significantly associated with age (r ¼ 0.192, P < 0.001), mean blood pressure (r ¼ 0.116, P ¼ 0.029), diastolic blood pressure (r ¼ 0.146, P ¼ 0.029), serum phosphorous (r ¼ 0.134, P ¼ 0.012), and lactate dehydrogenase (r ¼ 0.106, P ¼ 0.047). On the basis of age-adjusted multivariate linear regression analysis, carotid intima-media thickness was significantly correlated with serum phosphorous levels (b ¼ 0.273, P ¼ 0.022) in asymptomatic menopausal women. Increased carotid intima-media thickness (cut-off 1.5 mm) was detected, although serum phosphorous was within the normal range (2.8-4.5 mg/dL). Conclusions: Serum phosphorus concentration is significantly associated with carotid intima-media thickness in asymptomatic menopausal women.