Oligomerization Domains of G Protein-Coupled Receptors: Insights Into the Structural Basis of GPCR Association

Abstract

Many recent reviews have thoroughly described the ability of a wide range of G protein-coupled receptors (GPCRs) to exist and to potentially function as oligomers (1–6). This chapter summarizes the computational and experimental studies that have provided insight into the understanding of the structural basis of GPCR association. Particular emphasis is placed on the combined computational and experimental approach that we have recently developed to characterize the homodimerization interface of rhodopsin-like GPCRs.