Neuro-Protection after Traumatic Brain Injury: Novel Strategies.

Abstract

Traumatic brain injuries (TBI) are increasing cause of functional disability which requires aggressive researches on neuroprotective agents to prevent or rectify the consequences of organic brain dam age and to enhance rehabili tation. Many of the drugs which p roves beneficial in preclinical studies failed to translate into clinical practice, hence the search for the ideal neuroprotective drug continues. Since the p athophysiology of TBI is hig hly complex and variable with multiple factors play ing their roles simultaneously, it’s a very tiring job to find out a novel agent. When we try to alter one of the patho - physiological a spect of TBI, it affects many targets at a time , in the same manner as the waves affect the multiple points when we throw an object into pond. As the many aspects of the TBI are still obscured, it will be of great difficulty to search a suitable target which has got pronounced effect on TBI. The failure of newer molecules to fulfill its promise can also be attributed to the flaw in pre - clinical and clinical studies. Eventually the journey to have an ideal neuroprotective agent still continues