Abstract
(Figure Presented) Identified as nanomolar and selective Inhibitor of receptor protein kinase VEG FR3 (Flt4), the nontoxic and octahedrally coordinated IrIII complex 1 was synthesized by a stereoselective oxidative addition to a square-planar coordinated IrI precursor. The arrows in the image indicate positions at which the blood vessel formation in a zebrafish model of angiogenesis has been hampered by 1. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
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Wilbuer, A., Vlecken, D. H., Schmitz, D. J., Kräling, K., Harms, K., Bagowski, C. P., & Meggers, E. (2010). Iridium complex with antiangiogenic properties. Angewandte Chemie - International Edition, 49(22), 3839–3842. https://doi.org/10.1002/anie.201000682
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