Biomarkers of endometrial cancer

Abstract

EC is one of the commonest cancers worldwide, and its incidence is increasing particularly in the developed world. A patient usually presents with suspicious symptoms (typically PMB) and undergoes a range of investigations and treatment before a definitive diagnosis of EC is made (TVS, hysteroscopy and endometrial biopsy, CT/MRI, surgery for diagnosis, treatment and further staging). Biomarkers have the potential to help screening, diagnosing and staging the disease and could complement conventional means. At the moment, biomarker utilisation and research are more relevant in facilitating staging of EC and thus guiding treatment and aiding prognosis. Biomarker utilisation in screening and diagnosis is much less developed.