A new germacranolide and a new ceramide from Salvia nubicola (Lamiaceae)

Abstract

The methanol-soluble part of Salvia nubicola has yielded a new germacranolide and a new ceramide named nubtrienolide and nubenamide, respectively. Structures of both the isolated constituents were elucidated with the aid of spectroscopic techniques; the nubtrienolide structure was further confirmed via single crystal X-ray diffraction analysis. Among both the metabolites, nubtrienolide showed strong growth inhibition against Pseudomonas aeruginosa while during phytotoxicity testing, the same compound promoted the growth of Lemna minor L. instead to inhibit it. © 2007 Verlag der Zeitschrift für Naturforschung.