Neuroblast niche position is controlled by phosphoinositide 3-kinase-dependent DE-cadherin adhesion

12Citations
Citations of this article
59Readers
Mendeley users who have this article in their library.

Abstract

Correct positioning of stem cells within their niche is essential for tissue morphogenesis and homeostasis. How stem cells acquire and maintain niche position remains largely unknown. Here, we show that a subset of brain neuroblasts (NBs) in Drosophila utilize Phosphoinositide 3-kinase (PI3-kinase) and DE-cadherin to build adhesive contact for NB niche positioning. NBs remain within their native microenvironment when levels of PI3-kinase activity and DEcadherin are elevated in NBs. This occurs through PI3-kinasedependent regulation of DE-Cadherin-mediated cell adhesion between NBs and neighboring cortex glia, and between NBs and their ganglion mother cell daughters. When levels of PI3-kinase activity and/or DE-Cadherin are reduced in NBs, NBs lose niche position and relocate to a non-native brain region that is rich in neurosecretory neurons, including those that secrete some of the Drosophila insulin-like peptides. Linking levels of PI3-kinase activity to the strength of adhesive attachment could provide cancer stem cells and hematopoietic stem cells with a means to cycle from trophicpoor to trophic-rich microenvironments.

Cite

CITATION STYLE

APA

Doyle, S. E., Pahl, M. C., Siller, K. H., Ardiff, L., & Siegrist, S. E. (2017). Neuroblast niche position is controlled by phosphoinositide 3-kinase-dependent DE-cadherin adhesion. Development (Cambridge), 144(5), 820–829. https://doi.org/10.1242/dev.136713

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free