Gut microbiota and metabolic syndrome

Abstract

Metabolic syndrome is associated with current diseases, such as obesity, diabetes, hypertension, which are accompanied by changes in the intestinal microbiota and the functioning of the immune and neuro-humoral systems of the body. Without detracting from the role of heredity and environmental factors, the intestinal microbiota makes a significant contribution to the development of metabolic disorders and obesity by modulating cascading enzymatic reactions of the macroorganism, interacting with receptors directly and/or using its own metabolites and signaling molecules. The purpose of study was to analyze the literature data obtained in the study of the role of the intestinal microbiota in the development of metabolic syndrome (MS). Results: A review of current literature on the role of intestinal microbiota in the development of metabolic syndrome is presented. The features of the mucosal microflora of the colon, the role of bacterial films, epithelial lining of the intestinal mucosa in the formation of the intestinal microbial-tissue complex as the leading links of metabolic disorders are discussed. The article presents data on the variability of short-chain fatty acids, bacterial genome in the development of obesity and type 2 diabetes.