Abstract
Background: The role of ROS in FcγR signal transduction is unknown. Results: Deletion of gp91phox results in decreased IL-6 production and reduced Akt activation following FcγR engagement by immune complexes. Conclusion: Production of ROS via NOX2 is required for IL-6 production following FcγR engagement of immune complexes. Significance: ROS serves as a second messenger to facilitate FcγR signal transduction. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Cite
CITATION STYLE
Franchini, A. M., Hunt, D., Melendez, J. A., & Drake, J. R. (2013). FcγR-driven release of IL-6 by macrophages requires NOX2-dependent production of reactive oxygen species. Journal of Biological Chemistry, 288(35), 25098–25108. https://doi.org/10.1074/jbc.M113.474106
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
