Schizophrenia

Abstract

Despite a broad knowledge base about the pathology of schizophrenia, albeit fragmented and often inconsistent, no theme has emerged to link the illness with its molecular pathophysiology. There is insufficient certainty and consistency of findings to identify the critical molecular target on which to base therapeutic discovery. The most limiting aspect of schizophrenia therapeutics is this lack of critical knowledge with respect to its target pathophysiology, on which therapeutic strategies could be developed. © 2006 Humana Press Inc.