A simplified prognostic system for resected pancreatic neuroendocrine neoplasms

60Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Background: A number of prognostically relevant clinicopathological variables have been proposed for pancreatic neuroendocrine neoplasms. However, a standardized prognostication system has yet to be established for patients undergoing potentially curative tumour resection. Methods: We examined a prospectively maintained, single-institution database to identify patients who underwent potentially curative resection of non-metastatic primary pancreatic neuroendocrine neoplasms. Patient, operative and pathological characteristics were analysed to identify variables associated with disease-specific and disease-free survival. Results: Between 1991 and 2007, 43 patients met inclusion criteria. After a median follow-up of 68 months, 5-year disease-specific survival was 94% and 5-year disease-free survival was 72%. Tumours sized ≥5 cm and vascular invasion were associated with worse disease-specific survival. Tumours sized ≥5 cm, nodal metastases, positive resection margins and perineural invasion were associated with worse disease-free survival. A scoring system consisting of tumour size ≥5 cm, histological g rade, nodal metastases and resection margin positivity (SGNM) permitted stratification of disease-specific (P = 0.006) and disease-free (P = 0.0004) survival. This proposed scoring system demonstrated excellent discrimination of individual disease-specific and disease-free survival outcomes as reflected by concordance indices of 0.814 and 0.794, respectively. Conclusions: A simple scoring system utilizing tumour size, histological grade, nodal metastases and resection margin status can be used to stratify outcomes in patients undergoing resection of primary pancreatic neuroendocrine neoplasms. © 2009 International Hepato-Pancreato-Biliary Association.

References Powered by Scopus

Multivariable prognostic models: Issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors

8083Citations
N/AReaders
Get full text

The gastroenteropancreatic neuroendocrine cell system and its tumors: The WHO classification

693Citations
N/AReaders
Get full text

The diagnosis and medical management of advanced neuroendocrine tumors

576Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Sunitinib malate for the treatment of pancreatic neuroendocrine tumors

2203Citations
N/AReaders
Get full text

Neuroendocrine and adrenal tumors, version 2.2021

331Citations
N/AReaders
Get full text

The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors

281Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ballian, N., Loeffler, A. G., Rajammanickam, V., Norstedt, P. A., Weber, S. M., & Cho, C. S. (2009). A simplified prognostic system for resected pancreatic neuroendocrine neoplasms. HPB, 11(5), 422–428. https://doi.org/10.1111/j.1477-2574.2009.00082.x

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 10

77%

Professor / Associate Prof. 1

8%

Lecturer / Post doc 1

8%

Researcher 1

8%

Readers' Discipline

Tooltip

Medicine and Dentistry 11

79%

Computer Science 1

7%

Economics, Econometrics and Finance 1

7%

Arts and Humanities 1

7%

Save time finding and organizing research with Mendeley

Sign up for free