Steroids in COVID-19: Tailor-made or “one size fits all”?

Abstract

Since the RECOVERY trial, steroids have been endorsed by all guidelines for treating moderate-severe COVID-19. The prescribed dose is 6mg dexamethasone or its equivalent for ten days. However, in clinical practice, there are numerous occasions where the role of steroids cannot be extrapolated from current evidence: patients on immunosuppression, patients with persistent oxygen requirement after ten days of therapy, etc. We highlight the existing caveats and the need for further research and discussion.